CUTC
Copper homeostasis protein cutC homolog
Also known as: CGI-32, CUTC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NTM9
- Gene
- CUTC
- Ensembl
- ENSG00000119929
- Chromosome
- 10
- Canonical length
- 273 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Subcellular location
- Nucleoplasm,Nucleoli,Cytosol
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
273 residues, UniProt reviewed canonical sequence.
>Q9NTM9|CUTC
1 MKRQGASSER KRARIPSGKA GAANGFLMEV CVDSVESAVN AERGGADRIE LCSGLSEGGT
61 TPSMGVLQVV KQSVQIPVFV MIRPRGGDFL YSDREIEVMK ADIRLAKLYG ADGLVFGALT
121 EDGHIDKELC MSLMAICRPL PVTFHRAFDM VHDPMAALET LLTLGFERVL TSGCDSSALE
181 GLPLIKRLIE QAKGRIVVMP GGGITDRNLQ RILEGSGATE FHCSARSTRD SGMKFRNSSV
241 AMGASLSCSE YSLKVTDVTK VRTLNAIAKN ILVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CUTC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 361 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 361 nTPM
- tongue: 191 nTPM
- urinary bladder: 44 nTPM
- testis: 42 nTPM
- heart muscle: 40 nTPM
- adipose tissue: 37 nTPM
Single-cell type
- myonuclei: 340 nCPM
- cardiomyocytes: 191 nCPM
- late primary spermatocytes: 186 nCPM
- thymic myoid cells: 139 nCPM
- epididymal basal cells: 122 nCPM
- early primary spermatocytes: 117 nCPM
Immune cell
- eosinophil: 112 nTPM
- naive CD4 T-cell: 75 nTPM
- memory B-cell: 74 nTPM
- basophil: 71 nTPM
- neutrophil: 69 nTPM
- naive B-cell: 67 nTPM
Brain region
- white matter: 26 nTPM
- basal ganglia: 20 nTPM
- medulla oblongata: 19 nTPM
- cerebellum: 18 nTPM
- pons: 18 nTPM
- hypothalamus: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.84
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.58
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- CutC-like
- CutC-like domain superfamily
- CutC family
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CUTC as an antibody target. Whether an autoantibody or antibody against CUTC could matter depends on whether native CUTC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CUTC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CUTC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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