Seroatlas · Human Serome Atlas

CUSTOS

Protein CUSTOS

Also known as: C12orf43, CSTOS_HUMAN, FLJ12448

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96C57
Gene: CUSTOS
Ensembl: ENSG00000157895
Chromosome: 12
Canonical length: 262 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in Spemann organizer formation and negative regulation of Wnt signaling pathway. Predicted to be located in nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q96C57|CUSTOS
     1  MAAPSGTVSD SESSNSSSDA EELERCREAA MPAWGLEQRP HVAGKPRAGA ANSQLSTSQP
    61  SLRHKVNEHE QDGNELQTTP EFRAHVAKKL GALLDSFITI SEAAKEPAKA KVQKVALEDD
   121  GFRLFFTSVP GGREKEESPQ PRRKRQPSSS SEDSDEEWRR CREAAVSASD ILQESAIHSP
   181  GTVEKEAKKK RKLKKKAKKV ASVDSAVAAT TPTSMATVQK QKSGELNGDQ VSLGTKKKKK
   241  AKKASETSPF PPAKSATAIP AN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CUSTOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 17 nTPM
cerebellum: 11 nTPM
basal ganglia: 11 nTPM
amygdala: 11 nTPM
liver: 11 nTPM
ovary: 11 nTPM

Single-cell type

hepatic stellate cells: 39 nCPM
cytotrophoblasts: 30 nCPM
retinal pigment epithelial cells: 30 nCPM
migrating cytotrophoblasts: 30 nCPM
extravillous trophoblasts: 27 nCPM
megakaryocytes: 25 nCPM

Immune cell

naive CD4 T-cell: 28 nTPM
gdT-cell: 24 nTPM
memory B-cell: 24 nTPM
naive CD8 T-cell: 24 nTPM
T-reg: 24 nTPM
memory CD4 T-cell: 24 nTPM

Brain region

cerebral cortex: 23 nTPM
basal ganglia: 19 nTPM
pons: 17 nTPM
hippocampal formation: 17 nTPM
white matter: 16 nTPM
amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nuclear envelope

Protein domainsUniProt · Pfam · InterPro

Protein CUSTOS
CUSTOS

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CUSTOS as an antibody target. Whether an autoantibody or antibody against CUSTOS could matter depends on whether native CUSTOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CUSTOS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CUSTOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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