Seroatlas · Human Serome Atlas

CTXND2

Cortexin domain containing 2

Also known as: CTXD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GV90
Gene
CTXND2
Ensembl
ENSG00000283324
Chromosome
1
Canonical length
55 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

55 residues, UniProt reviewed canonical sequence.

>A0A1B0GV90|CTXND2
     1  MEDSSLSSGV DVDKGFAIAF VVLLFLFLIV MIFRCAKLVK NPYKASSTTT EPSLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTXND2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 0.8 nTPM
  • fallopian tube: 0.4 nTPM
  • testis: 0.2 nTPM
  • placenta: 0.1 nTPM
  • skeletal muscle: 0.1 nTPM
  • thymus: 0.1 nTPM

Single-cell type

  • oocytes: 14 nCPM
  • undifferentiated spermatogonia: 12 nCPM
  • extravillous trophoblasts: 9.7 nCPM
  • fallopian tube ciliated cells: 4.6 nCPM
  • granulosa cells: 4.1 nCPM
  • early primary spermatocytes: 2.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.1 nTPM
  • hypothalamus: 1 nTPM
  • pons: 1 nTPM
  • white matter: 1 nTPM
  • basal ganglia: 0.9 nTPM
  • cerebral cortex: 0.9 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTXND2 as an antibody target. Whether an autoantibody or antibody against CTXND2 could matter depends on whether native CTXND2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTXND2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTXND2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTXND2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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