Seroatlas · Human Serome Atlas

CTXND1

Cortexin domain-containing 1 protein

Also known as: CTXD1_HUMAN, LINC01314

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTU2
Gene
CTXND1
Ensembl
ENSG00000259417
Chromosome
15
Canonical length
59 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

59 residues, UniProt reviewed canonical sequence.

>A0A1B0GTU2|CTXND1
     1  MEEPTPEPVY VDVDKGLTLA CFVFLCLFLV VMIIRCAKVI MDPYSAIPTS TWEEQHLDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTXND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 25 nTPM
  • amygdala: 16 nTPM
  • hypothalamus: 9.3 nTPM
  • midbrain: 8.8 nTPM
  • liver: 8.7 nTPM
  • basal ganglia: 8.6 nTPM

Single-cell type

  • bergmann glia: 195 nCPM
  • astrocytes: 129 nCPM
  • oligodendrocyte progenitor cells: 106 nCPM
  • melanocytes: 79 nCPM
  • adrenal cortex cells: 76 nCPM
  • ependymal cells: 72 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 62 nTPM
  • thalamus: 27 nTPM
  • cerebral cortex: 25 nTPM
  • amygdala: 21 nTPM
  • midbrain: 20 nTPM
  • hypothalamus: 18 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTXND1 as an antibody target. Whether an autoantibody or antibody against CTXND1 could matter depends on whether native CTXND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTXND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTXND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTXND1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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