Seroatlas · Human Serome Atlas

CTXN2

Cortexin-2

Also known as: CTXN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C2S0
Gene
CTXN2
Ensembl
ENSG00000233932
Chromosome
15
Canonical length
81 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>P0C2S0|CTXN2
     1  MSSTYCGNSS AKMSVNEVSA FSLTLEQKTG FAFVGILCIF LGLLIIRCFK ILLDPYSSMP
    61  SSTWEDEVEE FDKGTFEYAL A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTXN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
2.2 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 2.2 nTPM
  • cerebral cortex: 2.1 nTPM
  • basal ganglia: 1.7 nTPM
  • amygdala: 1.3 nTPM
  • cerebellum: 1.3 nTPM
  • midbrain: 1.2 nTPM

Single-cell type

  • cardiomyocytes: 37 nCPM
  • late spermatids: 8.7 nCPM
  • epicardial cells: 6.8 nCPM
  • late primary spermatocytes: 5.8 nCPM
  • early spermatids: 5.4 nCPM
  • adipocytes: 2.5 nCPM

Immune cell

  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 3.7 nTPM
  • pons: 3.7 nTPM
  • cerebral cortex: 3 nTPM
  • medulla oblongata: 2.9 nTPM
  • midbrain: 2.8 nTPM
  • basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0.04
gnomAD missense Z
0.98
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTXN2 as an antibody target. Whether an autoantibody or antibody against CTXN2 could matter depends on whether native CTXN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTXN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTXN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTXN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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