Seroatlas · Human Serome Atlas

CTXN1

Cortexin-1

Also known as: CTXN1_HUMAN, FLJ25968

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60606
Gene
CTXN1
Ensembl
ENSG00000178531
Chromosome
19
Canonical length
82 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

82 residues, UniProt reviewed canonical sequence.

>P60606|CTXN1
     1  MSATWTLSPE PLPPSTGPPV GAGLDAEQRT VFAFVLCLLV VLVLLMVRCV RILLDPYSRM
    61  PASSWTDHKE ALERGQFDYA LV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTXN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
692 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 692 nTPM
  • hippocampal formation: 491 nTPM
  • amygdala: 420 nTPM
  • cerebral cortex: 410 nTPM
  • midbrain: 150 nTPM
  • hypothalamus: 149 nTPM

Single-cell type

  • fallopian tube ciliated cells: 312 nCPM
  • respiratory ciliated cells: 230 nCPM
  • epididymal principal cells: 131 nCPM
  • endometrial ciliated cells: 130 nCPM
  • ependymal cells: 124 nCPM
  • epididymal efferent duct ciliated cells: 115 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 754 nTPM
  • hippocampal formation: 598 nTPM
  • amygdala: 549 nTPM
  • cerebral cortex: 478 nTPM
  • hypothalamus: 360 nTPM
  • white matter: 267 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0.41
gnomAD missense Z
1.46
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTXN1 as an antibody target. Whether an autoantibody or antibody against CTXN1 could matter depends on whether native CTXN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTXN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTXN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTXN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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