Seroatlas · Human Serome Atlas

CTSZ

Cathepsin Z

Also known as: CATZ_HUMAN, CTSX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBR2
Gene: CTSZ
Ensembl: ENSG00000101160
Chromosome: 20
Canonical length: 303 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q9UBR2|CTSZ
     1  MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY PRPHEYLSPA
    61  DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA MADRINIKRK GAWPSTLLSV
   121  QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP DETCNNYQAK DQECDKFNQC GTCNEFKECH
   181  AIRNYTLWRV GDYGSLSGRE KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN
   241  HVVSVAGWGI SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD
   301  PIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTSZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 282 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 282 nTPM
lymph node: 254 nTPM
liver: 235 nTPM
lung: 213 nTPM
small intestine: 213 nTPM
duodenum: 203 nTPM

Single-cell type

hofbauer cells: 1,473 nCPM
cdc: 682 nCPM
macrophages: 640 nCPM
monocytes: 531 nCPM
kupffer cells: 484 nCPM
pdcs: 461 nCPM

Immune cell

non-classical monocyte: 2.9 nTPM
plasmacytoid DC: 1.8 nTPM
neutrophil: 1.6 nTPM
eosinophil: 1.5 nTPM
classical monocyte: 1.4 nTPM
intermediate monocyte: 1.4 nTPM

Brain region

choroid plexus: 113 nTPM
thalamus: 91 nTPM
white matter: 81 nTPM
hypothalamus: 59 nTPM
medulla oblongata: 54 nTPM
pons: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTSZ as an antibody target. Whether an autoantibody or antibody against CTSZ could matter depends on whether native CTSZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTSZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTSZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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