Seroatlas · Human Serome Atlas

CTSW

Cathepsin W

Also known as: CATW_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56202
Gene: CTSW
Ensembl: ENSG00000172543
Chromosome: 11
Canonical length: 376 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>P56202|CTSW
     1  MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN RSYLSPEEHA
    61  HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG QLYGYRRAAG GVPSMGREIR
   121  SEEPEESVPF SCDWRKVASA ISPIKDQKNC NCCWAMAAAG NIETLWRISF WDFVDVSVQE
   181  LLDCGRCGDG CHGGFVWDAF ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF
   241  IMLQNNEHRI AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS
   301  VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK GYFRLHRGSN TCGITKFPLT
   361  ARVQKPDMKP RVSCPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTSW can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 110 nTPM
spleen: 40 nTPM
lymph node: 28 nTPM
lung: 23 nTPM
tonsil: 13 nTPM
appendix: 12 nTPM

Single-cell type

nk-cells: 455 nCPM
platelets: 294 nCPM
t-cells: 192 nCPM
megakaryocytes: 192 nCPM
innate lymphoid cells: 146 nCPM
megakaryocyte progenitors: 139 nCPM

Immune cell

NK-cell: 2,281 nTPM
gdT-cell: 1,380 nTPM
memory CD8 T-cell: 893 nTPM
MAIT T-cell: 871 nTPM
total PBMC: 809 nTPM
naive CD8 T-cell: 638 nTPM

Brain region

cerebellum: 4 nTPM
medulla oblongata: 3.5 nTPM
spinal cord: 2.7 nTPM
pons: 2.6 nTPM
cerebral cortex: 2.5 nTPM
thalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: -0.67
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTSW as an antibody target. Whether an autoantibody or antibody against CTSW could matter depends on whether native CTSW is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTSW is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTSW as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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