Seroatlas · Human Serome Atlas

CTSV

Cathepsin L2

Also known as: CATL2_HUMAN, CTSL2, CTSU

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60911
Gene: CTSV
Ensembl: ENSG00000136943
Chromosome: 9
Canonical length: 334 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>O60911|CTSV
     1  MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE
    61  LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW
   121  RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG
   181  GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV
   241  ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK
   301  NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTSV can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 600 nTPM

Expression across tissuesHPA

Tissue

thymus: 600 nTPM
testis: 63 nTPM
skin: 47 nTPM
cervix: 41 nTPM
vagina: 22 nTPM
kidney: 20 nTPM

Single-cell type

ocular epithelial cells: 976 nCPM
medullary thymic epithelial cells: 651 nCPM
esophageal apical cells: 615 nCPM
sertoli cells: 249 nCPM
migrating cytotrophoblasts: 216 nCPM
extravillous trophoblasts: 212 nCPM

Immune cell

plasmacytoid DC: 15 nTPM
NK-cell: 3.5 nTPM
myeloid DC: 1.8 nTPM
naive B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

white matter: 2.6 nTPM
cerebellum: 2.4 nTPM
choroid plexus: 2.4 nTPM
cerebral cortex: 2.2 nTPM
amygdala: 2.1 nTPM
medulla oblongata: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTSV as an antibody target. Whether an autoantibody or antibody against CTSV could matter depends on whether native CTSV is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTSV is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTSV as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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