Seroatlas · Human Serome Atlas

CTSL3P

Putative inactive cathepsin L-like protein CTSL3P

Also known as: CATL3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5NE16
Gene: CTSL3P
Canonical length: 218 aa

OverviewNCBI Gene

No narrative summary is available for CTSL3P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q5NE16|CTSL3P
     1  MKMIEQHNQE YREGKHSFTM AMNAFGEMTS EEFRQVVNGF QNQKHRKGKV LQEPLLHDIR
    61  KSVDWREKGY VTPVKDQCNW GSVRTDVRKT EKLVSLSVQT WWTALGFKAM LAAFLENHYF
   121  ASSMLPTMEA WTLRKPFHMK KSSGDWKVQG HRGASGESLL ASGESQQSPE VAQYSGKHQV
   181  QCHLIEEALQ MLSGGDEDHD EDKWPHDMRN HLAGEAQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTSL3P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTSL3P as an antibody target. Whether an autoantibody or antibody against CTSL3P could matter depends on whether native CTSL3P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTSL3P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTSL3P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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