Seroatlas · Human Serome Atlas

CTRL

Chymotrypsin-like protease CTRL-1

Also known as: CTRL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P40313
Gene: CTRL
Ensembl: ENSG00000141086
Chromosome: 16
Canonical length: 264 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>P40313|CTRL
     1  MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS LQDSSGFHFC
    61  GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ VLSVSRAITH PSWNSTTMNN
   121  DVTLLKLASP AQYTTRISPV CLASSNEALT EGLTCVTTGW GRLSGVGNVT PAHLQQVALP
   181  LVTVNQCRQY WGSSITDSMI CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN
   241  VRAPAVYTRV SKFSTWINQV IAYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 7,054 nTPM

Expression across tissuesHPA

Tissue

pancreas: 7,054 nTPM
bone marrow: 5.8 nTPM
spleen: 5.4 nTPM
cerebellum: 3.9 nTPM
ovary: 3.6 nTPM
basal ganglia: 2.7 nTPM

Single-cell type

cardiomyocytes: 20 nCPM
pancreatic acinar cells: 7.9 nCPM
bergmann glia: 6.5 nCPM
epicardial cells: 4.5 nCPM
astrocytes: 3.9 nCPM
adipocytes: 3 nCPM

Immune cell

naive CD8 T-cell: 0.4 nTPM
neutrophil: 0.3 nTPM
gdT-cell: 0.2 nTPM
basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 4.8 nTPM
pons: 4.6 nTPM
medulla oblongata: 4.2 nTPM
white matter: 4.1 nTPM
cerebral cortex: 4 nTPM
thalamus: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTRL as an antibody target. Whether an autoantibody or antibody against CTRL could matter depends on whether native CTRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTRL is annotated as secreted, so native CTRL circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CTRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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