CTRC
Chymotrypsin-C
Also known as: CLCR, CTRC_HUMAN, ELA4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99895
- Gene
- CTRC
- Ensembl
- ENSG00000162438
- Chromosome
- 1
- Canonical length
- 268 aa
- Protein class
- Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
268 residues, UniProt reviewed canonical sequence.
>Q99895|CTRC
1 MLGITVLAAL LACASSCGVP SFPPNLSARV VGGEDARPHS WPWQISLQYL KNDTWRHTCG
61 GTLIASNFVL TAAHCISNTR TYRVAVGKNN LEVEDEEGSL FVGVDTIHVH KRWNALLLRN
121 DIALIKLAEH VELSDTIQVA CLPEKDSLLP KDYPCYVTGW GRLWTNGPIA DKLQQGLQPV
181 VDHATCSRID WWGFRVKKTM VCAGGDGVIS ACNGDSGGPL NCQLENGSWE VFGIVSFGSR
241 RGCNTRKKPV VYTRVSAYID WINEKMQLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CTRC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 12,513 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 12,513 nTPM
- ovary: 2.2 nTPM
- heart muscle: 2 nTPM
- salivary gland: 2 nTPM
- duodenum: 1.1 nTPM
- adipose tissue: 0.9 nTPM
Single-cell type
- pancreatic acinar cells: 27,400 nCPM
- pancreatic duct cells: 118 nCPM
- monocytes: 30 nCPM
- endometrial luminal cells: 10 nCPM
- mast cells: 9.7 nCPM
- pancreatic islet cells: 8.9 nCPM
Immune cell
- basophil: 0.6 nTPM
- neutrophil: 0.2 nTPM
- NK-cell: 0.2 nTPM
- naive B-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebellum: 3 nTPM
- cerebral cortex: 2.5 nTPM
- amygdala: 2.2 nTPM
- hippocampal formation: 2.2 nTPM
- pons: 2.2 nTPM
- thalamus: 2.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about CTRC.
Disease | AllUniProt
Conditions CTRC is implicated in, by any mechanism.
- Pancreatitis, hereditary (PCTT) MIM:167800
Disease | GeneticClinVar
17 pathogenic / likely-pathogenic of 754 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Hereditary pancreatitis
- Pancreatitis, chronic, susceptibility to
- Chronic pancreatitis
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.13
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CTRC as an antibody target. Whether an autoantibody or antibody against CTRC could matter depends on whether native CTRC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CTRC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CTRC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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