Seroatlas · Human Serome Atlas

CTHRC1

Collagen triple helix repeat-containing protein 1

Also known as: CTHR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CG8
Gene
CTHRC1
Ensembl
ENSG00000164932
Chromosome
8
Canonical length
243 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q96CG8|CTHRC1
     1  MRPQGPAASP QRLRGLLLLL LLQLPAPSSA SEIPKGKQKA QLRQREVVDL YNGMCLQGPA
    61  GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL
   121  GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ
   181  GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE
   241  LPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTHRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 85 nTPM
  • gallbladder: 82 nTPM
  • urinary bladder: 79 nTPM
  • adipose tissue: 68 nTPM
  • blood vessel: 59 nTPM
  • breast: 37 nTPM

Single-cell type

  • hepatic stellate cells: 278 nCPM
  • fibroblasts: 141 nCPM
  • lymphatic endothelial cells: 80 nCPM
  • plasma cells: 76 nCPM
  • thymocytes: 53 nCPM
  • epicardial cells: 43 nCPM

Immune cell

  • NK-cell: 2.3 nTPM
  • eosinophil: 0.8 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • cerebellum: 19 nTPM
  • cerebral cortex: 14 nTPM
  • white matter: 14 nTPM
  • pons: 12 nTPM
  • hypothalamus: 12 nTPM
  • medulla oblongata: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTHRC1.

Disease | AllUniProt

Conditions CTHRC1 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • CTHRC1, C-terminal domain
  • CTHRC1, C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTHRC1 as an antibody target. Whether an autoantibody or antibody against CTHRC1 could matter depends on whether native CTHRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTHRC1 is annotated as secreted, so native CTHRC1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CTHRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTHRC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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