Seroatlas · Human Serome Atlas

CTH

Cystathionine gamma-lyase

Also known as: CGL_HUMAN, CSE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32929
Gene
CTH
Ensembl
ENSG00000116761
Chromosome
1
Canonical length
405 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>P32929|CTH
     1  MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY
    61  SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY
   121  FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG
   181  DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGHSDV VMGLVSVNCE SLHNRLRFLQ
   241  NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH
   301  ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL
   361  KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
115 nTPM

Expression across tissuesHPA

Tissue

  • liver: 115 nTPM
  • ovary: 28 nTPM
  • pancreas: 16 nTPM
  • choroid plexus: 13 nTPM
  • kidney: 13 nTPM
  • adrenal gland: 12 nTPM

Single-cell type

  • hepatocytes: 189 nCPM
  • pancreatic acinar cells: 90 nCPM
  • endometrial ciliated cells: 82 nCPM
  • ovarian stromal cells: 81 nCPM
  • bergmann glia: 71 nCPM
  • cone photoreceptor cells: 70 nCPM

Immune cell

  • naive CD4 T-cell: 3.2 nTPM
  • MAIT T-cell: 2.2 nTPM
  • memory B-cell: 2.2 nTPM
  • memory CD8 T-cell: 1.7 nTPM
  • naive B-cell: 1.7 nTPM
  • naive CD8 T-cell: 1.5 nTPM

Brain region

  • choroid plexus: 9.6 nTPM
  • hypothalamus: 7.8 nTPM
  • midbrain: 7.8 nTPM
  • pons: 7.4 nTPM
  • cerebral cortex: 7.2 nTPM
  • medulla oblongata: 7.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTH.

Disease | AllUniProt

Conditions CTH is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 110 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cystathioninuria

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
0.41
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • CALM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTH as an antibody target. Whether an autoantibody or antibody against CTH could matter depends on whether native CTH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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