Seroatlas · Human Serome Atlas

CTAGE9

cTAGE family member 9

Also known as: CTGE9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A4FU28
Gene
CTAGE9
Ensembl
ENSG00000236761
Chromosome
6
Canonical length
777 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein secretion; and vesicle cargo loading. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>A4FU28|CTAGE9
     1  MEEPGATPQP YLGLVLEELG RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
    61  RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
   121  AAEEARSLEA TCEKLSRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
   181  SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGQVSE
   241  LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELKVNSQ
   301  WENGANLDDP PKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
   361  TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE
   421  EKISHATEEL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
   481  KENAHNKQKL TERELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ
   541  TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP
   601  VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE
   661  MESSRNDAKD DLGNLNVPDS SLPAENEATG PGLIPPPLAP ISGPLFPVDT RGPFMRRGPP
   721  FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTAGE9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9 nTPM
  • skin: 0.4 nTPM
  • salivary gland: 0.3 nTPM
  • thyroid gland: 0.3 nTPM
  • esophagus: 0.2 nTPM
  • kidney: 0.2 nTPM

Single-cell type

  • late primary spermatocytes: 22 nCPM
  • early spermatids: 4.6 nCPM
  • late spermatids: 0.3 nCPM
  • suprabasal keratinocytes: 0.3 nCPM
  • early primary spermatocytes: 0.2 nCPM
  • leydig cells: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.5 nTPM
  • cerebral cortex: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • thalamus: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.22
DepMap mean gene effect
-0.44
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTAGE9 as an antibody target. Whether an autoantibody or antibody against CTAGE9 could matter depends on whether native CTAGE9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTAGE9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTAGE9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTAGE9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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