Seroatlas · Human Serome Atlas

CTAGE8

cTAGE family member 8

Also known as: CTGE8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG41
Gene: CTAGE8
Ensembl: ENSG00000289604
Chromosome: 7
Canonical length: 777 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein secretion; and vesicle cargo loading. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>P0CG41|CTAGE8
     1  MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
    61  RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
   121  AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
   181  SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGQVSE
   241  LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
   301  WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
   361  TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE
   421  EKISRATEGL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
   481  KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ
   541  TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP
   601  VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE
   661  MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP
   721  FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTAGE8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

skin: 6.4 nTPM
thyroid gland: 4.8 nTPM
testis: 2.8 nTPM
small intestine: 2.7 nTPM
duodenum: 2.1 nTPM
stomach: 2 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 3.5 nTPM
midbrain: 0.8 nTPM
amygdala: 0.7 nTPM
hypothalamus: 0.7 nTPM
medulla oblongata: 0.7 nTPM
pons: 0.7 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

cTAGE and MIA/OTOR

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTAGE8 as an antibody target. Whether an autoantibody or antibody against CTAGE8 could matter depends on whether native CTAGE8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTAGE8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTAGE8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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