Seroatlas · Human Serome Atlas

CTAGE6

cTAGE family member 6

Also known as: CTAGE6P, CTGE6_HUMAN, MGC41943

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UF2
Gene
CTAGE6
Ensembl
ENSG00000271321
Chromosome
7
Canonical length
777 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein secretion; and vesicle cargo loading. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>Q86UF2|CTAGE6
     1  MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
    61  RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
   121  AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
   181  SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGEVSE
   241  LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
   301  WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
   361  TQQESLQSEN IYFESENQKL QQKLKIMTEF YQEDEMKLYR KLTVEENYRI EEEEKLSKVE
   421  EKLSRATEQL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
   481  KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHAP NGPAPLGQRS SETRAFLSPQ
   541  TLLEDPLGLS PVLPEGGGRG PRGPGNPLDH QITNERGEPS CDRLTDPHRA PSDTGSLSSP
   601  VEQDCKMMFP PPGQSYPDSA LPPQREDRFY SNSERLSGSA EPRSFKMTSL DKMDGSMPSE
   661  MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP
   721  FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYFHPRPG FYPNPAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTAGE6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • testis: 14 nTPM
  • esophagus: 0.2 nTPM
  • kidney: 0.2 nTPM
  • cervix: 0.1 nTPM
  • lung: 0.1 nTPM
  • ovary: 0.1 nTPM

Single-cell type

  • podocytes: 0.5 nCPM
  • papillary tip epithelial cells: 0.4 nCPM
  • renal connecting tubule cells: 0.3 nCPM
  • renal collecting duct intercalated cells: 0.2 nCPM
  • b-cells: 0.1 nCPM
  • distal convoluted tubule cells: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1 nTPM
  • cerebral cortex: 0.9 nTPM
  • cerebellum: 0.7 nTPM
  • midbrain: 0.7 nTPM
  • thalamus: 0.7 nTPM
  • medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTAGE6 as an antibody target. Whether an autoantibody or antibody against CTAGE6 could matter depends on whether native CTAGE6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTAGE6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTAGE6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTAGE6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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