Seroatlas · Human Serome Atlas

CTAGE1

cTAGE family member 2

Also known as: CT21.1, CT21.2, CTAGE, cTAGE-1, cTAGE-2, CTGE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RT6
Gene: CTAGE1
Ensembl: ENSG00000212710
Chromosome: 18
Canonical length: 745 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein secretion; and vesicle cargo loading. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

745 residues, UniProt reviewed canonical sequence.

>Q96RT6|CTAGE1
     1  MRPDSHPYGF PWELVIRAAV AGFFAVLFLW RSFRSVTSRL YVRREKKFAV ALSGLIEEKC
    61  KLLEKFSLVQ KEYEGYEVES SLKNASFEKE ATEAQSLEAT CEKLNRFNSE LVHEILCLEK
   121  ELKEEKSKHS EQNELMADIS KRIQSLEDES KSLKSQVAEA KMTFKRFQAN EERLEIEIQD
   181  AWKENSELQE SQKQLLQEAE VWKEQVSELI KQKRTFEDSK VHAEQVLNDK ENHIKTLTER
   241  LLKMKDGVAM LEEDVTDDDN LELEMNSESE DGAYLDNPPK GALKKLIHAA KLNASLKTLE
   301  GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FESENQKLQQ KLKVMTELYQ
   361  ENEMKLYRKL IVEEKCRLEK EEKLSKVDEM ISHATEELET YRKRAKDLKE FEKTIHFYQK
   421  KIILHEKKAH DNWSAAWTAE RNLNDLRKEN AHNRQKLTEI EFKIKLLEKD PYGLDVPNTA
   481  FGRQHSPYGP SPLGWPSSET RASLYPPTLL EGPLRLSPLL PRGGGRGSRG PGNPPDHQIT
   541  KERGESSCDR LTDPHRAPSD AGPLAPPWEQ DYRMMFPPPG QSYPDSALPP QRQDRFYSNC
   601  ARLSGPAELR SFNMPSLDKM DGSMPSEMES SRNDTKDNLG NLKVPDSSLP AENEATGPGF
   661  VPPPLAPIRG LLFPVDTRGP FIRRGPPFPP PPPGTVFGAS PDYFSPRDVP GPPRAPFAMR
   721  NVYLPRGFLP YRPPRPAFFP PAPTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTAGE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

testis: 9.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

proximal tubule cells: 6.7 nCPM
renal connecting tubule cells: 2.7 nCPM
renal collecting duct principal cells: 2.5 nCPM
loop of henle epithelial cells: 2.3 nCPM
renal collecting duct intercalated cells: 2.2 nCPM
papillary tip epithelial cells: 2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTAGE1.

Disease | ImmuneIEDB

Conditions an epitope on CTAGE1 was assayed in.

colorectal cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -2.67
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

cTAGE and MIA/OTOR

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTAGE1 as an antibody target. Whether an autoantibody or antibody against CTAGE1 could matter depends on whether native CTAGE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTAGE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTAGE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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