CTAG1A

Protein identityUniProt · HPA

UniProt accession

P78358

Gene

CTAG1A

Ensembl

ENSG00000268651

Chromosome

X

Canonical length

180 aa

Protein class

Cancer-related genes, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>P78358|CTAG1A
     1  MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA
    61  PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG
   121  VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTAG1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

7.6 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTAG1A.

Disease | ImmuneIEDB

Conditions an epitope on CTAG1A was assayed in.

• skin melanoma T cell
• ovarian cancer T cell
• melanoma B and T cell
• gastric adenocarcinoma T cell
• hepatocellular carcinoma T cell
• lung adenocarcinoma T cell
• prostate cancer B and T cell
• stomach cancer T cell
• esophageal cancer T cell
• lung non-small cell carcinoma T cell
• cancer T cell
• glioblastoma T cell
• cholangiocarcinoma T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against CTAG1A are reported. Each links to that disease's full target list.

• Lung Neoplasms 4
• Ovarian Neoplasms 3

ReferencesPubMed · IEDB

Publications for CTAG1A from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• tRNA threonylcarbamoyladenosine metabolic process

Molecular functions

• identical protein binding

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• CTAG/Pcc1 family
• Transcription factor Pcc1

KeywordsUniProt

• Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of CTAG1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAGEC1