CT83
Kita-kyushu lung cancer antigen 1
Also known as: CXorf61, FLJ20611, FLJ22913, KK-LC-1, KKLC1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5H943
- Gene
- CT83
- Ensembl
- ENSG00000204019
- Chromosome
- X
- Canonical length
- 113 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
113 residues, UniProt reviewed canonical sequence.
>Q5H943|CT83
1 MNFYLLLASS ILCALIVFWK YRRFQRNTGE MSSNSTALAL VRPSSSGLIN SNTDNNLAVY
61 DLSRDILNNF PHSIARQKRI LVNLSMVENK LVELEHTLLS KGFRGASPHR KSTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CT83 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 66 nTPM
Expression across tissuesHPA
Tissue
- testis: 66 nTPM
- salivary gland: 2.6 nTPM
- stomach: 0.2 nTPM
- breast: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- late spermatids: 4,894 nCPM
- early spermatids: 852 nCPM
- late primary spermatocytes: 303 nCPM
- gastric progenitor cells: 18 nCPM
- leydig cells: 4 nCPM
- breast lactating cells: 2.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about CT83.
Disease | ImmuneIEDB
Conditions an epitope on CT83 was assayed in.
- cervix carcinoma T cell
- squamous cell carcinoma T cell
- cervical adenocarcinoma T cell
- lung adenocarcinoma T cell
- lung squamous cell carcinoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0.08
- gnomAD missense Z
- -0.01
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Kita-kyushu lung cancer antigen 1
- Kita-kyushu lung cancer antigen 1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CT83 as an antibody target. Whether an autoantibody or antibody against CT83 could matter depends on whether native CT83 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CT83 is annotated at the cell surface, where native CT83 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CT83 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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