CT47B1
Cancer/testis antigen family 47 member B1
Also known as: CT47.13, CT47B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0C2W7
- Gene
- CT47B1
- Ensembl
- ENSG00000236446
- Chromosome
- X
- Canonical length
- 299 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli
OverviewNCBI Gene
No narrative summary is available for CT47B1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
299 residues, UniProt reviewed canonical sequence.
>P0C2W7|CT47B1
1 MSATGDRHPT QGDQEAPVSQ EGAQAEAAGA GNQEGGDSGP DSSDMVPAAE VVGVAGPVEG
61 LGEEEGEQAA GLAAVPQGGS AEEDSDIGPA TEEEEEEEEG NEAANFDLAV ATRRYPAAGI
121 GFVFLYLVHS LLRRLYHNDH IQIANRHLSR LMVGPHAAVP NLWDNPPLLL LSQRLGAGAA
181 APEGEGLGLI QEAASVQEAA SVPEPAVPAD LAEMAREPAE EAADEKPPEE AAEEKLTEEA
241 TEEPAAEEPT SEEAVAPEEV TKSQPEKWDE EAQDAAGEEE KEQEKEKDVE NKVKNSKGTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CT47B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 7 nTPM
Expression across tissuesHPA
Tissue
- testis: 7 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- early primary spermatocytes: 121 nCPM
- differentiating spermatogonia: 24 nCPM
- undifferentiated spermatogonia: 7.6 nCPM
- late primary spermatocytes: 1.4 nCPM
- late spermatids: 0.7 nCPM
- sertoli cells: 0.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -6.06
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CT47B1 as an antibody target. Whether an autoantibody or antibody against CT47B1 could matter depends on whether native CT47B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CT47B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CT47B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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