Seroatlas · Human Serome Atlas

CT47A1

Cancer/testis antigen 47A

Also known as: CT47.1, CT47.10, CT47.11, CT47.12, CT47.2, CT47.3, CT47.4, CT47.5, CT47.6, CT47.7, CT47.8, CT47.9, CT47A_HUMAN, CT47A10, CT47A11, CT47A12, CT47A2, CT47A3, CT47A4, CT47A5, CT47A6, CT47A7, CT47A8, CT47A9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JQC4
Gene
CT47A1
Ensembl
ENSG00000236371
Chromosome
X
Canonical length
288 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

This locus represents a member of the cancer/testis gene family 47. This family, also known as CT47, is comprised of 13 nearly identical loci clustered at Xq24. This locus is the most telomeric of the cluster.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q5JQC4|CT47A1
     1  MSATGDRHPT QGDQEAPVSQ EGAQAEAAGA GNQEGGDSGP DSSDVVPAAE VVGVAGPVEG
    61  LGEEEGEQAA GLAAVPRGGS AEEDSDIGPA TEEEEEEEGN EAANFDLAVV ARRYPASGIH
   121  FVLLDMVHSL LHRLSHNDHI LIENRQLSRL MVGPHAAARN LWGNLPPLLL PQRLGAGAAA
   181  RAGEGLGLIQ EAASVPEPAV PADLAEMARE PAEEAAEEKL SEEATEEPDA EEPATEEPTA
   241  QEATAPEEVT KSQPEKWDEE AQDAAGEEEK EQEKEKDAEN KVKNSKGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CT47A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CT47A1 as an antibody target. Whether an autoantibody or antibody against CT47A1 could matter depends on whether native CT47A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CT47A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CT47A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CT47A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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