CST6
Cystatin-M
Also known as: CYTM_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15828
- Gene
- CST6
- Ensembl
- ENSG00000175315
- Chromosome
- 11
- Canonical length
- 149 aa
- Protein class
- Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
- Subcellular location
- Plasma membrane,Cytosol
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
149 residues, UniProt reviewed canonical sequence.
>Q15828|CST6
1 MARSNLPLAL GLALVAFCLL ALPRDARARP QERMVGELRD LSPDDPQVQK AAQAAVASYN
61 MGSNSIYYFR DTHIIKAQSQ LVAGIKYFLT MEMGSTDCRK TRVTGDHVDL TTCPLAAGAQ
121 QEKLRCDFEV LVVPWQNSSQ LLKHNCVQMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CST6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 1,027 nTPM
Expression across tissuesHPA
Tissue
- skin: 1,027 nTPM
- blood vessel: 49 nTPM
- esophagus: 46 nTPM
- cervix: 39 nTPM
- thyroid gland: 28 nTPM
- breast: 27 nTPM
Single-cell type
- esophageal apical cells: 1,346 nCPM
- alveolar cells type 1: 329 nCPM
- fallopian tube ciliated cells: 283 nCPM
- migrating cytotrophoblasts: 184 nCPM
- respiratory ciliated cells: 158 nCPM
- esophageal suprabasal cells: 84 nCPM
Immune cell
- classical monocyte: 0.2 nTPM
- myeloid DC: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebellum: 1.7 nTPM
- choroid plexus: 1.7 nTPM
- hypothalamus: 1 nTPM
- cerebral cortex: 0.9 nTPM
- medulla oblongata: 0.5 nTPM
- white matter: 0.5 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about CST6.
Disease | AllUniProt
Conditions CST6 is implicated in, by any mechanism.
- Ectodermal dysplasia 15, hypohidrotic/hair type (ECTD15) MIM:618535
Disease | GeneticClinVar
2 pathogenic / likely-pathogenic of 30 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Ectodermal dysplasia 15, hypohidrotic/hair type
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0.37
- gnomAD missense Z
- 1.25
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CST6 as an antibody target. Whether an autoantibody or antibody against CST6 could matter depends on whether native CST6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CST6 is annotated as secreted, so native CST6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CST6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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