CST5
Cystatin-D
Also known as: CYTD_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P28325
- Gene
- CST5
- Ensembl
- ENSG00000170367
- Chromosome
- 20
- Canonical length
- 142 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
142 residues, UniProt reviewed canonical sequence.
>P28325|CST5
1 MMWPMHTPLL LLTALMVAVA GSASAQSRTL AGGIHATDLN DKSVQCALDF AISEYNKVIN
61 KDEYYSRPLQ VMAAYQQIVG GVNYYFNVKF GRTTCTKSQP NLDNCPFNDQ PKLKEEEFCS
121 FQINEVPWED KISILNYKCR KVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CST5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 2,026 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 2,026 nTPM
- pancreas: 2.1 nTPM
- smooth muscle: 1.4 nTPM
- lung: 1.2 nTPM
- adrenal gland: 0.9 nTPM
- heart muscle: 0.4 nTPM
Single-cell type
- salivary acinar cells: 462 nCPM
- salivary myoepithelial cells: 67 nCPM
- epididymal efferent duct absorptive cells: 24 nCPM
- neutrophils: 12 nCPM
- lacrimal acinar cells: 8.2 nCPM
- salivary duct cells: 5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.34
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CST5 as an antibody target. Whether an autoantibody or antibody against CST5 could matter depends on whether native CST5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CST5 is annotated as secreted, so native CST5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CST5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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