CST11
Cystatin-11
Also known as: CST11_HUMAN, CST8L, CTES2, dJ322G13.6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H112
- Gene
- CST11
- Ensembl
- ENSG00000125831
- Chromosome
- 20
- Canonical length
- 138 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]
Canonical amino-acid sequenceUniProt
138 residues, UniProt reviewed canonical sequence.
>Q9H112|CST11
1 MMAEPWQALQ LLLAILLTLM ALPYQARKKT FLSVHEVMAV ENYAKDSLQW ITDQYNKESD
61 DKYHFRIFRV LKVQRQVTDH LEYHLNVEMQ WTTCQKPETT NCVPQERELH KQVNCFFSVF
121 AVPWFEQYKI LNKSCSSDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CST11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 199 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 199 nTPM
- testis: 0.4 nTPM
- stomach: 0.3 nTPM
- thymus: 0.2 nTPM
- colon: 0.1 nTPM
- kidney: 0.1 nTPM
Single-cell type
- epididymal principal cells: 1,141 nCPM
- decidual stromal cells: 54 nCPM
- epididymal basal cells: 16 nCPM
- epididymal clear cells: 14 nCPM
- esophageal apical cells: 6.1 nCPM
- epididymal efferent duct absorptive cells: 3.9 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- pons: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.39
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- androgen receptor signaling pathway
- defense response to Gram-negative bacterium
- killing of cells of another organism
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CST11 as an antibody target. Whether an autoantibody or antibody against CST11 could matter depends on whether native CST11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CST11 is annotated as secreted, so native CST11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CST11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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