CSRNP3

Protein identityUniProt · HPA

UniProt accession

Q8WYN3

Gene

CSRNP3

Ensembl

ENSG00000178662

Chromosome

2

Canonical length

585 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nucleoli rim

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q8WYN3|CSRNP3
     1  MSGILKRKFE EVDGSSPCSS VRESDDEVSS SESADSGDSV NPSTSSHFTP SSILKREKRL
    61  RTKNVHFSCV TVYYFTRRQG FTSVPSQGGS TLGMSSRHNS VRQYTLGEFA REQERLHREM
   121  LREHLREEKL NSLKLKMTKN GTVESEEAST LTLDDISDDD IDLDNTEVDE YFFLQPLPTK
   181  KRRALLRASG VKKIDVEEKH ELRAIRLSRE DCGCDCRVFC DPDTCTCSLA GIKCQVDRMS
   241  FPCGCTKEGC SNTAGRIEFN PIRVRTHFLH TIMKLELEKN REQQIPTLNG CHSEISAHSS
   301  SMGPVAHSVE YSIADSFEIE TEPQAAVLHL QSAEELDCQG EEEEEEEDGS SFCSGVTDSS
   361  TQSLAPSESD EEEEEEEEEE EEEDDDDDKG DGFVEGLGTH AEVVPLPSVL CYSDGTAVHE
   421  SHAKNASFYA NSSTLYYQID SHIPGTPNQI SENYSERDTV KNGTLSLVPY TMTPEQFVDY
   481  ARQAEEAYGA SHYPAANPSV IVCCSSSEND SGVPCNSLYP EHRSNHPQVE FHSYLKGPSQ
   541  EGFVSALNGD SHISEHPAEN SLSLAEKSIL HEECIKSPVV ETVPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSRNP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

9.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.5

gnomAD missense Z

1.59

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• positive regulation of apoptotic process
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• sequence-specific DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Cysteine/serine-rich nuclear protein family
• Cysteine/serine-rich nuclear protein, N-terminal domain
• Cysteine/serine-rich nuclear protein N-terminus

KeywordsUniProt

• Activator
• Apoptosis
• DNA-binding
• Nucleus
• Transcription
• Transcription regulation