CSNK2A3

Protein identityUniProt · HPA

UniProt accession

Q8NEV1

Gene

CSNK2A3

Ensembl

ENSG00000254598

Chromosome

11

Canonical length

391 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q8NEV1|CSNK2A3
     1  MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT
    61  NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD
   121  FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE
   181  FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWRLGC MLASMIFRKE PFFHGRDNYD
   241  QLVRIAKFLG TEDLYGYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF
   301  LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN VMSGISSVPT
   361  PSPLGPLAGS PVIAAANPLG MPVPAATGAQ Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK2A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

1.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.71

gnomAD pLI

0

gnomAD missense Z

-0.63

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• double-strand break repair
• positive regulation of cell growth
• positive regulation of cell population proliferation
• positive regulation of protein catabolic process
• protein phosphorylation
• regulation of cell cycle

Molecular functions

• ATP binding
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• cytosol
• nucleoplasm
• nucleus
• protein kinase CK2 complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Casein Kinase 2, subunit alpha
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• Kinase
• Nucleotide-binding
• Proto-oncogene
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of CSNK2A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PML