Seroatlas · Human Serome Atlas

CSNK1G3

Casein kinase I isoform gamma-3

Also known as: KC1G3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6M4
Gene: CSNK1G3
Ensembl: ENSG00000151292
Chromosome: 5
Canonical length: 447 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q9Y6M4|CSNK1G3
     1  MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG
    61  KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG
   121  PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKTQQV
   181  IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM
   241  YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD
   301  YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH QHRDKMQQSK
   361  NQSADHRAAW DSQQANPHHL RAHLAADRHG GSVQVVSSTN GELNTDDPTA GRSNAPITAP
   421  TEVEVMDETK CCCFFKRRKR KTIQRHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK1G3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

liver: 24 nTPM
rectum: 23 nTPM
small intestine: 23 nTPM
colon: 21 nTPM
duodenum: 21 nTPM
urinary bladder: 19 nTPM

Single-cell type

b-cells: 157 nCPM
innate lymphoid cells: 150 nCPM
retinal horizontal cells: 146 nCPM
nk-cells: 123 nCPM
lactotrophs: 120 nCPM
choroid plexus epithelial cells: 118 nCPM

Immune cell

NK-cell: 14 nTPM
memory B-cell: 13 nTPM
basophil: 13 nTPM
naive B-cell: 13 nTPM
MAIT T-cell: 8.9 nTPM
T-reg: 7.6 nTPM

Brain region

cerebellum: 35 nTPM
hypothalamus: 29 nTPM
cerebral cortex: 27 nTPM
basal ganglia: 27 nTPM
hippocampal formation: 27 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 2.75
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK1G3 as an antibody target. Whether an autoantibody or antibody against CSNK1G3 could matter depends on whether native CSNK1G3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK1G3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK1G3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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