Seroatlas · Human Serome Atlas

CSN3

Kappa-casein

Also known as: CASK_HUMAN, CSN10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07498
Gene
CSN3
Ensembl
ENSG00000171209
Chromosome
4
Canonical length
182 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in female reproductive system

OverviewNCBI Gene

Involved in lactation and protein stabilization. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>P07498|CSN3
     1  MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY VPNSYPYYGT
    61  NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP NSHPPTVVRR PNLHPSFIAI
   121  PPKKIQDKII IPTINTIATV EPTPAPATEP TVDSVVTPEA FSESIITSTP ETTTVAVTPP
   181  TA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
337 nTPM

Expression across tissuesHPA

Tissue

  • breast: 337 nTPM
  • salivary gland: 64 nTPM
  • lymph node: 0.2 nTPM
  • testis: 0.2 nTPM
  • tonsil: 0.2 nTPM
  • pancreas: 0.1 nTPM

Single-cell type

  • breast lactating cells: 25,926 nCPM
  • salivary acinar cells: 176 nCPM
  • lacrimal acinar cells: 44 nCPM
  • salivary myoepithelial cells: 28 nCPM
  • submucosal glandular cells: 22 nCPM
  • breast secretory cells: 11 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 1.3 nTPM
  • thalamus: 0.4 nTPM
  • hypothalamus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.71
gnomAD pLI
0.01
gnomAD missense Z
-0.03
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Kappa casein
  • Kappa casein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSN3 as an antibody target. Whether an autoantibody or antibody against CSN3 could matter depends on whether native CSN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSN3 is annotated as secreted, so native CSN3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CSN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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