Seroatlas · Human Serome Atlas

CSKMT

Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial

Also known as: CS-KMT, CSKMT_HUMAN, METTL12, U99HG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MUP2
Gene: CSKMT
Ensembl: ENSG00000214756
Chromosome: 11
Canonical length: 240 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; and peptidyl-lysine trimethylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>A8MUP2|CSKMT
     1  MAALRRMLHL PSLMMGTCRP FAGSLADSCL ADRCLWDRLH AQPRLGTVPT FDWFFGYDEV
    61  QGLLLPLLQE AQAASPLRVL DVGCGTSSLC TGLYTKSPHP VDVLGVDFSP VAVAHMNSLL
   121  EGGPGQTPLC PGHPASSLHF MHADAQNLGA VASSGSFQLL LDKGTWDAVA RGGLPRAYQL
   181  LSECLRVLNP QGTLIQFSDE DPDVRLPCLE QGSYGWTVTV QELGPFRGIT YFAYLIQGSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSKMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 0.9 nTPM
pancreas: 0.7 nTPM
ovary: 0.6 nTPM
cervix: 0.5 nTPM
duodenum: 0.5 nTPM
esophagus: 0.5 nTPM

Single-cell type

colonocytes: 115 nCPM
breast myoepithelial cells: 79 nCPM
hepatic stellate cells: 78 nCPM
breast secretory cells: 69 nCPM
enterocytes: 67 nCPM
goblet cells: 59 nCPM

Immune cell

memory B-cell: 2.7 nTPM
naive CD4 T-cell: 2.7 nTPM
naive CD8 T-cell: 2.4 nTPM
memory CD4 T-cell: 2.3 nTPM
intermediate monocyte: 1.7 nTPM
MAIT T-cell: 1.6 nTPM

Brain region

hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
thalamus: 0.2 nTPM
amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM
choroid plexus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSKMT as an antibody target. Whether an autoantibody or antibody against CSKMT could matter depends on whether native CSKMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSKMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSKMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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