Seroatlas · Human Serome Atlas

CRTAM

Cytotoxic and regulatory T-cell molecule

Also known as: CD355, CRTAM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95727
Gene: CRTAM
Ensembl: ENSG00000109943
Chromosome: 11
Canonical length: 393 aa
Protein class: CD markers, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>O95727|CRTAM
     1  MWWRVLSLLA WFPLQEASLT NHTETITVEE GQTLTLKCVT SLRKNSSLQW LTPSGFTIFL
    61  NEYPALKNSK YQLLHHSANQ LSITVPNVTL QDEGVYKCLH YSDSVSTKEV KVIVLATPFK
   121  PILEASVIRK QNGEEHVVLM CSTMRSKPPP QITWLLGNSM EVSGGTLHEF ETDGKKCNTT
   181  STLIIHTYGK NSTVDCIIRH RGLQGRKLVA PFRFEDLVTD EETASDALER NSLSSQDPQQ
   241  PTSTVSVTED SSTSEIDKEE KEQTTQDPDL TTEANPQYLG LARKKSGILL LTLVSFLIFI
   301  LFIIVQLFIM KLRKAHVIWK KENEVSEHTL ESYRSRSNNE ETSSEEKNGQ SSHPMRCMNY
   361  ITKLYSEAKT KRKENVQHSK LEEKHIQVPE SIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRTAM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 128 nTPM
lymph node: 8.2 nTPM
thymus: 4.5 nTPM
spleen: 3.3 nTPM
tonsil: 3.2 nTPM
spinal cord: 2.5 nTPM

Single-cell type

t-cells: 128 nCPM
nk-cells: 74 nCPM
brain excitatory neurons: 53 nCPM
innate lymphoid cells: 21 nCPM
thymocytes: 21 nCPM
monocytes: 10 nCPM

Immune cell

NK-cell: 54 nTPM
naive CD8 T-cell: 33 nTPM
memory CD8 T-cell: 27 nTPM
gdT-cell: 13 nTPM
MAIT T-cell: 13 nTPM
non-classical monocyte: 10 nTPM

Brain region

cerebellum: 79 nTPM
pons: 8.9 nTPM
white matter: 3.6 nTPM
midbrain: 3.2 nTPM
cerebral cortex: 3.1 nTPM
medulla oblongata: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin domain subtype
Immunoglobulin-like domain
Immunoglobulin V-set domain
CD80-like, immunoglobulin C2-set
Immunoglobulin-like fold
Immunoglobulin-like domain superfamily
Immunoglobulin V-set domain
CD80-like C2-set immunoglobulin domain
Cytotoxic and regulatory T-cell molecule

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRTAM as an antibody target. Whether an autoantibody or antibody against CRTAM could matter depends on whether native CRTAM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRTAM is annotated at the cell surface, where native CRTAM is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CRTAM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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