Seroatlas · Human Serome Atlas

CROCCP3

Putative ciliary rootlet coiled-coil protein-like 2 protein

Also known as: CROL2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVE0
Gene: CROCCP3
Canonical length: 287 aa

OverviewNCBI Gene

No narrative summary is available for CROCCP3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q8IVE0|CROCCP3
     1  MRGRYEASQD LLGTLRKQLS DSESERRALE EQLQRLRDKT DSTMQAHEDA QREVQRLRSA
    61  KELLRREKSN LAHSLQVAQQ QAKELRQERK KLQAAQEELR RQRYWLGEEQ EDAVQDGVRV
   121  RRELERSHRQ LEQLEGKRSV LAKELVEVRE ALSRATLQRD MLQAEKAEVA EALTKAEGRG
   181  GLPAGLPVQA ERPQREPCSG QVGSEPPCHP GHSWRKKSAP CRAGSGRRSR RPQWHGKSRS
   241  GWRRCGWNRR WRGRAWRAPY ERRSRPRRQW SSSSPRCIMS AAGCRSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CROCCP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CROCCP3 as an antibody target. Whether an autoantibody or antibody against CROCCP3 could matter depends on whether native CROCCP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CROCCP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CROCCP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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