Seroatlas · Human Serome Atlas

CROCCP2

Putative ciliary rootlet coiled-coil protein-like 1 protein

Also known as: CROL1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86T23
Gene: CROCCP2
Canonical length: 111 aa

OverviewNCBI Gene

No narrative summary is available for CROCCP2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

111 residues, UniProt reviewed canonical sequence.

>Q86T23|CROCCP2
     1  MLQAKKTEVA EALTKAEAGR MELELSVTKL RAEEASLQDS LSKLSALNES LAQDKLDLNC
    61  LVTQLEEEKA MLQGRQRQAE QEATVAPAEQ EWLEELWLEQ EVARQGLEGS L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CROCCP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CROCCP2 as an antibody target. Whether an autoantibody or antibody against CROCCP2 could matter depends on whether native CROCCP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CROCCP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CROCCP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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