Seroatlas · Human Serome Atlas

CROCC2

Ciliary rootlet coiled-coil protein 2

Also known as: CRCC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H7BZ55
Gene: CROCC2
Ensembl: ENSG00000226321
Chromosome: 2
Canonical length: 1653 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be active in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1653 residues, UniProt reviewed canonical sequence.

>H7BZ55|CROCC2
     1  MSSASSEPGN GDASQQPLLG LDTVIQRLED TILSPTASRE DRALTVRGEG RQASPTPVPT
    61  RIREIVAGSL SEEPPQAGVQ EPTATVARVQ EENELLQEEL TRLGDLLAQA SAERDELASR
   121  CRVVSEQLQA RLETTEAQLR RSELEHSVDL EEALGRLEAA EERSTGLCQV NALLREQLEH
   181  MKKANDALGR ELAGMTGSVQ RLQGELELRR WAQRQTRSGG LGQPRDLLLL WRQAVVLGTD
   241  LAELRVATER GLADLQADTA RTARRLHTAC LNLDSNLRLS ASSTASTLGQ QLRDKAGEML
   301  QLQGRWDAEK VALQARLSEQ TLLVEKLTEQ NEQKAKTIAA LRTDLQNLVA QEDARCLELA
   361  GSSITELGEP RRPLRSPQRA TSPHQGASPP HICSPATLDP ALQAMRAAIE RRWRREQELC
   421  LQLKSSQALV ASLQEQLSES RRELWAAQKL QQERAREQAR EREALRGQLE AQRLEVQQCR
   481  ASCKLLGREK AALEMVVEEL KGKADAADAE KQGLEAEAAE LQRSLLLQAE RREELALRRE
   541  RSCRALETSQ GRLQQLEEKV SGLREELASV REALSTAQLQ RDVVESEREG LRSALARAEC
   601  SNADLELLVR RLKSEGVEQR DSLAAMAALM EGLAQDKSAL NHLALQLEQE RDQLREQRKT
   661  LEQERARAGE QLAQAEQQLA LERAERRGLQ QACGRLEQRQ EQLEGQAALL GREKAQLQEQ
   721  VGQVTCQKQA LEEQLAQSLQ DQEAQMGTLQ QALQGKDALS EERAQLLAKQ EALERQGRLA
   781  AEEAADLRVE RDSLESSLLE AQQLATKLQE QLEEEARSAG LARQALQVEM EQLQSDWEVQ
   841  EMKLRQDTVR LQRQVAQQER EAQRALESQA LAHREALAQL QREKETLSLT LAEEKEVARC
   901  QLEQEKELVT KSAAEREALK GEIQSLKQER DESLLQLEHK MQQALSLKET ERSLLSEELS
   961  RARRTLERVQ QEAQSQQEQA QATISATTEE LKALQAQFED AITAHQRETT ALRESLQDLA
  1021  AERGDVEREA ERLRAQLTVA QEGLAALRQE LQGVEESREG LHREAQEARR ALSDEAREKD
  1081  VLLLFNSELR ATICRAEQEK ASFKRSKEEK EQKLLILEEA QAALQQEASA LRAHLWELEQ
  1141  AGGDARQELR ELHRQVRTLK AENQRRSGEA HELQAQCSQE VLELRRQAAK AEAKHEGARK
  1201  EVLGLQRKLA EVEAAGEAHG QRLQEHLRES RGAEQTLRAE LHSVTRKLQE ASGVADALQA
  1261  RLDQACHRIH SLEQELAQAE GARQDAEAQL GRLCSTLRRG LGLQRQSPWA SPEQPGSPTK
  1321  GSDSSQALPG QQGTSPPARP HSPLRWPSPT PGGRSSELMD VATVQDILRD FVQKLREAQR
  1381  ERDDSRIQMA TLSSRLSEAE CRCARAQSRV GQLQKALAEA EEGQRRVEGA LSSARAARAL
  1441  QKEALRRLEL EHLASVRAAG QEKRRLQEQL ETLRQALEES RRHSQGLAKQ GKLLEEQLTN
  1501  LEHRCQKAEV SLEPLRQMEQ ETLKREEDVA RLGAEKEQLD QSLNSLHQEV DGALRQNQQL
  1561  QAQMTEMEQA HTQRLQDLTA QHQRDLATEA ERLHGARPQA TQALESQEWT HQQQVKVLEE
  1621  QVASLKEQLD QEVQWRQQAH LGQAFQTGHA QRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CROCC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 5.1 nTPM
choroid plexus: 3 nTPM
spleen: 2.1 nTPM
lung: 0.6 nTPM
lymph node: 0.6 nTPM
small intestine: 0.3 nTPM

Single-cell type

ependymal cells: 284 nCPM
respiratory ciliated cells: 203 nCPM
endometrial ciliated cells: 195 nCPM
fallopian tube ciliated cells: 128 nCPM
epididymal efferent duct ciliated cells: 117 nCPM
thyrotrophs: 89 nCPM

Immune cell

non-classical monocyte: 0.7 nTPM
intermediate monocyte: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 50 nTPM
midbrain: 14 nTPM
medulla oblongata: 6.5 nTPM
pons: 5.2 nTPM
hippocampal formation: 3.9 nTPM
spinal cord: 3.4 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CROCC2 as an antibody target. Whether an autoantibody or antibody against CROCC2 could matter depends on whether native CROCC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CROCC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CROCC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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