CRNN

Protein identityUniProt · HPA

UniProt accession

Q9UBG3

Gene

CRNN

Ensembl

ENSG00000143536

Chromosome

1

Canonical length

495 aa

Protein class

Disease related genes, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the """"""""""""""""""""""""""""""""fused gene"""""""""""""""""""""""""""""""" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q9UBG3|CRNN
     1  MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL
    61  LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG
   121  TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS
   181  PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ
   241  TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ
   301  TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ
   361  DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST ESGRQEWSST
   421  HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG
   481  ITARELYSYL RSTKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRNN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

5,228 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CRNN.

Disease | AllUniProt

Conditions CRNN is implicated in, by any mechanism.

• Esophageal cancer (ESCR) MIM:133239

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.37

gnomAD pLI

0

gnomAD missense Z

-0.5

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell adhesion
• cellular response to cytokine stimulus
• positive regulation of cell cycle G1/S phase transition
• positive regulation of keratinocyte proliferation
• positive regulation of NF-kappaB transcription factor activity
• regulation of gene expression
• regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• response to heat

Molecular functions

• calcium ion binding
• calcium-dependent protein binding
• transition metal ion binding

Cellular components

• cytoplasm
• extracellular exosome
• membrane

Protein domainsUniProt · Pfam · InterPro

• EF-hand domain
• EF-hand domain pair
• S100/CaBP-9k-type, calcium binding, subdomain
• EF-Hand 1, calcium-binding site
• S-100
• S-100/ICaBP type calcium binding domain

KeywordsUniProt

• Calcium
• Cytoplasm
• Metal-binding