CRLF2

Protein identityUniProt · HPA

UniProt accession

Q9HC73

Gene

CRLF2

Ensembl

ENSG00000205755

Chromosome

X

Canonical length

371 aa

Protein class

Cancer-related genes, Human disease related genes, Predicted membrane proteins

Subcellular location

Plasma membrane

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q9HC73|CRLF2
     1  MGRLVLLWGA AVFLLGGWMA LGQGGAAEGV QIQIIYFNLE TVQVTWNASK YSRTNLTFHY
    61  RFNGDEAYDQ CTNYLLQEGH TSGCLLDAEQ RDDILYFSIR NGTHPVFTAS RWMVYYLKPS
   121  SPKHVRFSWH QDAVTVTCSD LSYGDLLYEV QYRSPFDTEW QSKQENTCNV TIEGLDAEKC
   181  YSFWVRVKAM EDVYGPDTYP SDWSEVTCWQ RGEIRDACAE TPTPPKPKLS KFILISSLAI
   241  LLMVSLLLLS LWKLWRVKKF LIPSVPDPKS IFPGLFEIHQ GNFQEWITDT QNVAHLHKMA
   301  GAEQESGPEE PLVVQLAKTE AESPRMLDPQ TEEKEASGGS LQLPHQPLQG GDVVTIGGFT
   361  FVMNDRSYVA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRLF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

1.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.4

gnomAD pLI

0

gnomAD missense Z

-0.85

OntologyGO

Biological processes

• cytokine-mediated signaling pathway
• positive regulation of cell population proliferation
• positive regulation of interleukin-5 production
• positive regulation of mast cell activation
• positive regulation of receptor signaling pathway via STAT

Molecular functions

• coreceptor activity
• cytokine binding
• cytokine receptor activity

Cellular components

• external side of plasma membrane
• extracellular region
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Fibronectin type III
• Immunoglobulin-like fold
• Fibronectin type III superfamily
• Cytokine receptor-like factor 2-like, D2 domain
• Cytokine receptor-like factor 2-like, domain 1
• Cytokine receptor-like factor 2-like, D2 domain
• Cytokine receptor-like factor 2, domain 1

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Secreted
• Signal
• Transmembrane
• Transmembrane helix