Seroatlas · Human Serome Atlas

CRIPTO3

Protein CRIPTO3

Also known as: CR-3, CRIPTO-3, TDGF1P3, TDGF2, TDGF3, TDGF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51864
Gene
CRIPTO3
Ensembl
ENSG00000225366
Chromosome
X
Canonical length
188 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The TDGF3 locus has characteristics of a retrotransposon, including lack of introns and a poly(A) sequence. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>P51864|CRIPTO3
     1  MDCRKMVRFS YSVIWIMAIS KAFELGLVAG LGHQEFARPS RGDLAFRDDS IWPQEEPAIR
    61  PRSSQRVLPM GIQHSKELNR TCCLNGGTCM LESFCACPPS FYGRNCEHDV RKENCGSVPH
   121  DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD GLVMDEHLVA SRTPELPPSA RTTTFMLAGI
   181  CLSIQSYY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRIPTO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM
  • breast: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.2 nTPM
  • cerebral cortex: 0.9 nTPM
  • amygdala: 0.8 nTPM
  • choroid plexus: 0.8 nTPM
  • hippocampal formation: 0.8 nTPM
  • hypothalamus: 0.8 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRIPTO3 as an antibody target. Whether an autoantibody or antibody against CRIPTO3 could matter depends on whether native CRIPTO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRIPTO3 is annotated at the cell surface, where native CRIPTO3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CRIPTO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRIPTO3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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