Seroatlas · Human Serome Atlas

CRIP3

Cysteine-rich protein 3

Also known as: bA480N24.2, CRIP3_HUMAN, TLP, TLP-A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6Q6R5
Gene: CRIP3
Ensembl: ENSG00000146215
Chromosome: 6
Canonical length: 217 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to act upstream of or within T cell proliferation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q6Q6R5|CRIP3
     1  MSWTCPRCQQ PVFFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR PYCHKPCYGA
    61  LFGPRGVNIG GVGSYLYNPP TPSPGCTTPL SPSSFSPPRP RTGLPQGKKS PPHMKTFTGE
   121  TSLCPGCGEP VYFAEKVMSL GRNWHRPCLR CQRCHKTLTA GSHAEHDGVP YCHVPCYGYL
   181  FGPKGGQPHP RHWDGMYMPE VWHVHGLWVC VDNFPCG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
heart muscle: 23 nTPM
cerebellum: 15 nTPM
basal ganglia: 9.8 nTPM
liver: 9.5 nTPM
spleen: 7.8 nTPM

Single-cell type

late spermatids: 14 nCPM
cardiomyocytes: 8.1 nCPM
astrocytes: 7.2 nCPM
late primary spermatocytes: 7.2 nCPM
oligodendrocyte progenitor cells: 7.2 nCPM
bergmann glia: 5.9 nCPM

Immune cell

myeloid DC: 45 nTPM
classical monocyte: 2.7 nTPM
naive B-cell: 2.6 nTPM
memory B-cell: 2.3 nTPM
non-classical monocyte: 2.3 nTPM
total PBMC: 1.8 nTPM

Brain region

cerebellum: 8.1 nTPM
hypothalamus: 6.6 nTPM
cerebral cortex: 6.3 nTPM
white matter: 6 nTPM
basal ganglia: 5.7 nTPM
hippocampal formation: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

metal ion binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRIP3 as an antibody target. Whether an autoantibody or antibody against CRIP3 could matter depends on whether native CRIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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