Seroatlas · Human Serome Atlas

CRIP1

Cysteine-rich protein 1

Also known as: CRIP, CRIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50238
Gene: CRIP1
Ensembl: ENSG00000213145
Chromosome: 14
Canonical length: 77 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

77 residues, UniProt reviewed canonical sequence.

>P50238|CRIP1
     1  MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP YCNHPCYAAM
    61  FGPKGFGRGG AESHTFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 549 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 549 nTPM
small intestine: 294 nTPM
epididymis: 195 nTPM
lung: 193 nTPM
skin: 173 nTPM
heart muscle: 154 nTPM

Single-cell type

enterocytes: 4,888 nCPM
epididymal efferent duct ciliated cells: 2,456 nCPM
endometrial ciliated cells: 1,717 nCPM
epididymal principal cells: 1,640 nCPM
vascular smooth muscle cells: 1,104 nCPM
cdc: 686 nCPM

Immune cell

memory B-cell: 700 nTPM
T-reg: 697 nTPM
total PBMC: 466 nTPM
myeloid DC: 444 nTPM
memory CD4 T-cell: 443 nTPM
naive B-cell: 387 nTPM

Brain region

midbrain: 28 nTPM
medulla oblongata: 24 nTPM
spinal cord: 18 nTPM
pons: 13 nTPM
thalamus: 11 nTPM
choroid plexus: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRIP1 as an antibody target. Whether an autoantibody or antibody against CRIP1 could matter depends on whether native CRIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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