CRHBP
Corticotropin-releasing factor-binding protein
Also known as: CRF-BP, CRFBP, CRHBP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P24387
- Gene
- CRHBP
- Ensembl
- ENSG00000145708
- Chromosome
- 5
- Canonical length
- 322 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
322 residues, UniProt reviewed canonical sequence.
>P24387|CRHBP
1 MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC
61 LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG
121 EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL
181 FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI
241 GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ
301 LEPYELENPN GNSIGEFCLS GLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CRHBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 156 nTPM
Expression across tissuesHPA
Tissue
- liver: 156 nTPM
- hypothalamus: 57 nTPM
- kidney: 42 nTPM
- spleen: 35 nTPM
- adipose tissue: 21 nTPM
- adrenal gland: 15 nTPM
Single-cell type
- hematopoietic stem cells: 2,019 nCPM
- megakaryocyte-erythroid progenitors: 214 nCPM
- vascular endothelial cells: 123 nCPM
- kupffer cells: 65 nCPM
- thymocytes: 63 nCPM
- megakaryocyte progenitors: 20 nCPM
Immune cell
- neutrophil: 0.1 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- thalamus: 38 nTPM
- hypothalamus: 30 nTPM
- pons: 22 nTPM
- midbrain: 16 nTPM
- cerebral cortex: 13 nTPM
- medulla oblongata: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.58
- gnomAD pLI
- 0.21
- gnomAD missense Z
- 1.35
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- behavioral response to ethanol
- cellular response to calcium ion
- cellular response to cAMP
- cellular response to cocaine
- cellular response to estradiol stimulus
- cellular response to estrogen stimulus
- cellular response to gonadotropin-releasing hormone
- cellular response to potassium ion
- cellular response to tumor necrosis factor
- cellular response to xenobiotic stimulus
- female pregnancy
- hormone metabolic process
- hormone-mediated signaling pathway
- inflammatory response
- learning or memory
- maternal aggressive behavior
- regulated exocytosis
- regulation of cellular response to stress
- regulation of NMDA receptor activity
- signal transduction
- synaptic transmission, dopaminergic
- negative regulation of corticotropin secretion
- negative regulation of corticotropin-releasing hormone receptor activity
- regulation of corticotropin secretion
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Spermadhesin, CUB domain superfamily
- Corticotropin-releasing factor-binding protein
- Corticotropin-releasing factor binding protein, N-terminal domain
- Corticotropin-releasing factor binding protein, C-terminal domain
- Corticotropin-releasing factor binding protein N-terminal domain
- Corticotropin-releasing factor binding protein C-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CRHBP as an antibody target. Whether an autoantibody or antibody against CRHBP could matter depends on whether native CRHBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CRHBP is annotated as secreted, so native CRHBP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CRHBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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