Seroatlas · Human Serome Atlas

CRH

Corticoliberin

Also known as: CRF, CRF_HUMAN, CRH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P06850
Gene: CRH
Ensembl: ENSG00000147571
Chromosome: 8
Canonical length: 196 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>P06850|CRH
     1  MRLPLLVSAG VLLVALLPCP PCRALLSRGP VPGARQAPQH PQPLDFFQPP PQSEQPQQPQ
    61  ARPVLLRMGE EYFLRLGNLN KSPAAPLSPA SSLLAGGSGS RPSPEQATAN FFRVLLQQLL
   121  LPRRSLDSPA ALAERGARNA LGGHQEAPER ERRSEEPPIS LDLTFHLLRE VLEMARAEQL
   181  AQQAHSNRKL MEIIGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 53 nTPM
cerebral cortex: 13 nTPM
amygdala: 6.7 nTPM
placenta: 6.2 nTPM
basal ganglia: 4.5 nTPM
hippocampal formation: 4.4 nTPM

Single-cell type

syncytiotrophoblasts: 250 nCPM
pancreatic islet cells: 148 nCPM
other brain neurons: 35 nCPM
brain inhibitory neurons: 24 nCPM
early spermatids: 19 nCPM
late spermatids: 17 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 318 nTPM
thalamus: 50 nTPM
pons: 39 nTPM
hypothalamus: 22 nTPM
midbrain: 20 nTPM
cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.72
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

corticotropin-releasing hormone receptor 1 binding
corticotropin-releasing hormone receptor 2 binding
hormone activity
neuropeptide hormone activity
signaling receptor binding
corticotropin-releasing hormone activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CRHR1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRH as an antibody target. Whether an autoantibody or antibody against CRH could matter depends on whether native CRH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRH is annotated as secreted, so native CRH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CRH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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