CREG1
Protein CREG1
Also known as: CREG, CREG1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75629
- Gene
- CREG1
- Ensembl
- ENSG00000143162
- Chromosome
- 1
- Canonical length
- 220 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Vesicles,Microtubules
- Secretome location
- Secreted to blood
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
220 residues, UniProt reviewed canonical sequence.
>O75629|CREG1
1 MAGLSRGSAR ALLAALLAST LLALLVSPAR GRGGRDHGDW DEASRLPPLP PREDAARVAR
61 FVTHVSDWGA LATISTLEAV RGRPFADVLS LSDGPPGAGS GVPYFYLSPL QLSVSNLQEN
121 PYATLTMTLA QTNFCKKHGF DPQSPLCVHI MLSGTVTKVN ETEMDIAKHS LFIRHPEMKT
181 WPSSHNWFFA KLNITNIWVL DYFGGPKIVT PEEYYNVTVQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CREG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 276 nTPM
Expression across tissuesHPA
Tissue
- liver: 276 nTPM
- spleen: 129 nTPM
- kidney: 123 nTPM
- adipose tissue: 122 nTPM
- adrenal gland: 121 nTPM
- gallbladder: 120 nTPM
Single-cell type
- kupffer cells: 1,210 nCPM
- hofbauer cells: 1,020 nCPM
- esophageal apical cells: 306 nCPM
- macrophages: 275 nCPM
- esophageal suprabasal cells: 251 nCPM
- platelets: 224 nCPM
Immune cell
- classical monocyte: 129 nTPM
- myeloid DC: 90 nTPM
- eosinophil: 76 nTPM
- intermediate monocyte: 76 nTPM
- non-classical monocyte: 73 nTPM
- total PBMC: 58 nTPM
Brain region
- white matter: 90 nTPM
- thalamus: 67 nTPM
- choroid plexus: 62 nTPM
- medulla oblongata: 59 nTPM
- spinal cord: 57 nTPM
- cerebral cortex: 53 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.42
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- autophagy
- endocytosis
- lysosomal lumen acidification
- lysosome organization
- regulation of transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CREG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CREG1 as an antibody target. Whether an autoantibody or antibody against CREG1 could matter depends on whether native CREG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CREG1 is annotated as secreted, so native CREG1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CREG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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