CREBRF

Protein identityUniProt · HPA

UniProt accession

Q8IUR6

Gene

CREBRF

Ensembl

ENSG00000164463

Chromosome

5

Canonical length

639 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>Q8IUR6|CREBRF
     1  MPQPSVSGMD PPFGDAFRSH TFSEQTLMST DLLANSSDPD FMYELDREMN YQQNPRDNFL
    61  SLEDCKDIEN LESFTDVLDN EGALTSNWEQ WDTYCEDLTK YTKLTSCDIW GTKEVDYLGL
   121  DDFSSPYQDE EVISKTPTLA QLNSEDSQSV SDSLYYPDSL FSVKQNPLPS SFPGKKITSR
   181  AAAPVCSSKT LQAEVPLSDC VQKASKPTSS TQIMVKTNMY HNEKVNFHVE CKDYVKKAKV
   241  KINPVQQSRP LLSQIHTDAA KENTCYCGAV AKRQEKKGME PLQGHATPAL PFKETQELLL
   301  SPLPQEGPGS LAAGESSSLS ASTSVSDSSQ KKEEHNYSLF VSDNLGEQPT KCSPEEDEED
   361  EEDVDDEDHD EGFGSEHELS ENEEEEEEEE DYEDDKDDDI SDTFSEPGYE NDSVEDLKEV
   421  TSISSRKRGK RRYFWEYSEQ LTPSQQERML RPSEWNRDTL PSNMYQKNGL HHGKYAVKKS
   481  RRTDVEDLTP NPKKLLQIGN ELRKLNKVIS DLTPVSELPL TARPRSRKEK NKLASRACRL
   541  KKKAQYEANK VKLWGLNTEY DNLLFVINSI KQEIVNRVQN PRDERGPNMG QKLEILIKDT
   601  LGLPVAGQTS EFVNQVLEKT AEGNPTGGLV GLRIPTSKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREBRF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.61

Highest tissue expression

64 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.1

gnomAD pLI

1

gnomAD missense Z

2.36

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• maternal behavior
• negative regulation of endoplasmic reticulum unfolded protein response
• negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway
• negative regulation of transcription by RNA polymerase II
• positive regulation of protein catabolic process
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• response to endoplasmic reticulum stress
• response to unfolded protein
• positive regulation of prolactin signaling pathway

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• cytoplasm
• nuclear body
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Basic-leucine zipper domain
• Basic-leucine zipper domain superfamily
• CREB3 regulatory factor

KeywordsUniProt

• Nucleus
• Repressor
• Stress response
• Transcription
• Transcription regulation
• Transport
• Unfolded protein response