Seroatlas · Human Serome Atlas

CREB3L4

Cyclic AMP-responsive element-binding protein 3-like protein 4

Also known as: AIbZIP, ATCE1, CR3L4_HUMAN, CREB3, CREB4, hJAL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEY5
Gene: CREB3L4
Ensembl: ENSG00000143578
Chromosome: 1
Canonical length: 395 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane,Mitochondria

OverviewNCBI Gene

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q8TEY5|CREB3L4
     1  MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW KSGGDRGCGL
    61  QESEPEDFLK LFIDPNEVYC SEASPGSDSG ISEDPCHPDS PPAPRATSSP MLYEVVYEAG
   121  ALERMQGETG PNVGLISIQL DQWSPAFMVP DSCMVSELPF DAHAHILPRA GTVAPVPCTT
   181  LLPCQTLFLT DEEKRLLGQE GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE
   241  YIDGLESRVA ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI
   301  LLFSLALIIL PSFSPFQSRP EAGSEDYQPH GVTSRNILTH KDVTENLETQ VVESRLREPP
   361  GAKDANGSTR TLLEKMGGKP RPSGRIRSVL HADEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREB3L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

prostate: 100 nTPM
breast: 45 nTPM
salivary gland: 42 nTPM
cervix: 29 nTPM
stomach: 28 nTPM
fallopian tube: 18 nTPM

Single-cell type

prostatic glandular cells: 154 nCPM
gastric chief cells: 73 nCPM
goblet cells: 62 nCPM
breast hormone-responsive cells: 60 nCPM
mucous neck cells: 55 nCPM
breast secretory cells: 36 nCPM

Immune cell

NK-cell: 9.4 nTPM
plasmacytoid DC: 5.7 nTPM
myeloid DC: 5 nTPM
naive B-cell: 4.8 nTPM
MAIT T-cell: 4.5 nTPM
memory B-cell: 4.5 nTPM

Brain region

cerebellum: 4.9 nTPM
white matter: 4.9 nTPM
choroid plexus: 4.6 nTPM
midbrain: 4.1 nTPM
medulla oblongata: 3.7 nTPM
spinal cord: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CREB3L4 as an antibody target. Whether an autoantibody or antibody against CREB3L4 could matter depends on whether native CREB3L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CREB3L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CREB3L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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