Seroatlas · Human Serome Atlas

CREB3L2

Cyclic AMP-responsive element-binding protein 3-like protein 2

Also known as: BBF2H7, CR3L2_HUMAN, TCAG_1951439

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q70SY1
Gene
CREB3L2
Ensembl
ENSG00000182158
Chromosome
7
Canonical length
520 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location
Nucleoplasm,Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q70SY1|CREB3L2
     1  MEVLESGEQG VLQWDRKLSE LSEPGDGEAL MYHTHFSELL DEFSQNVLGQ LLNDPFLSEK
    61  SVSMEVEPSP TSPAPLIQAE HSYSLCEEPR AQSPFTHITT SDSFNDDEVE SEKWYLSTDF
   121  PSTSIKTEPV TDEPPPGLVP SVTLTITAIS TPLEKEEPPL EMNTGVDSSC QTIIPKIKLE
   181  PHEVDQFLNF SPKEAPVDHL HLPPTPPSSH GSDSEGSLSP NPRLHPFSLP QTHSPSRAAP
   241  RAPSALSSSP LLTAPHKLQG SGPLVLTEEE KRTLIAEGYP IPTKLPLSKS EEKALKKIRR
   301  KIKNKISAQE SRRKKKEYMD SLEKKVESCS TENLELRKKV EVLENTNRTL LQQLQKLQTL
   361  VMGKVSRTCK LAGTQTGTCL MVVVLCFAVA FGSFFQGYGP YPSATKMALP SQHSLQEPYT
   421  ASVVRSRNLL IYEEHSPPEE SSSPGSAGEL GGWDRGSSLL RVSGLESRPD VDLPHFIISN
   481  ETSLEKSVLL ELQQHLVSAK LEGNETLKVV ELDRRVNTTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREB3L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 61 nTPM
  • parathyroid gland: 56 nTPM
  • blood vessel: 46 nTPM
  • placenta: 37 nTPM
  • choroid plexus: 32 nTPM
  • endometrium: 31 nTPM

Single-cell type

  • plasma cells: 698 nCPM
  • choroid plexus epithelial cells: 342 nCPM
  • syncytiotrophoblasts: 325 nCPM
  • corticotrophs: 309 nCPM
  • salivary acinar cells: 304 nCPM
  • extravillous trophoblasts: 243 nCPM

Immune cell

  • T-reg: 13 nTPM
  • plasmacytoid DC: 12 nTPM
  • basophil: 9.9 nTPM
  • MAIT T-cell: 9.8 nTPM
  • memory CD8 T-cell: 8.2 nTPM
  • gdT-cell: 7.3 nTPM

Brain region

  • choroid plexus: 102 nTPM
  • white matter: 40 nTPM
  • thalamus: 38 nTPM
  • cerebral cortex: 34 nTPM
  • basal ganglia: 33 nTPM
  • medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CREB3L2 as an antibody target. Whether an autoantibody or antibody against CREB3L2 could matter depends on whether native CREB3L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CREB3L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CREB3L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CREB3L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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