CRCT1
Cysteine-rich C-terminal protein 1
Also known as: C1orf42, CRCT1_HUMAN, NICE-1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UGL9
- Gene
- CRCT1
- Ensembl
- ENSG00000169509
- Chromosome
- 1
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for CRCT1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q9UGL9|CRCT1
1 MSSQQSAVSA KGFSKGSSQG PAPCPAPAPT PAPASSSSCC GSGRGCCGDS GCCGSSSTSC
61 CCFPRRRRRQ RSSGCCCCGG GSQRSQRSNN RSSGCCSGCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CRCT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 1,887 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 1,887 nTPM
- vagina: 807 nTPM
- cervix: 641 nTPM
- skin: 289 nTPM
- salivary gland: 269 nTPM
- tonsil: 17 nTPM
Single-cell type
- esophageal apical cells: 83,038 nCPM
- esophageal suprabasal cells: 659 nCPM
- suprabasal keratinocytes: 640 nCPM
- esophageal basal cells: 108 nCPM
- submucosal glandular cells: 74 nCPM
- ocular epithelial cells: 16 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.39
- DepMap mean gene effect
- -0.4
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Cysteine-rich C-terminal protein 1
- Cysteine-rich C-terminal 1 family
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CRCT1 as an antibody target. Whether an autoantibody or antibody against CRCT1 could matter depends on whether native CRCT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CRCT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CRCT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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