Seroatlas · Human Serome Atlas

CRACR2B

EF-hand calcium-binding domain-containing protein 4A

Also known as: EFC4A_HUMAN, EFCAB4A, MGC45840

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4Y2
Gene: CRACR2B
Ensembl: ENSG00000177685
Chromosome: 11
Canonical length: 399 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Involved in store-operated calcium entry. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q8N4Y2|CRACR2B
     1  MASPGKPGAD EAQEEEGELE GGSAGPRAAI LEQAEELFLL CDKEAKGFIT KHDLQGLQSD
    61  LPLTPEQLEA VFESLDRAHT GFLTAREFCL GLGMFVGVAS AQGANPCRTP EETFESGGLD
   121  VQGTAGSLDE EEEEEERFHT VLEQLGVAPV LGKQRAVRTL WARLQRERPE LLGSFEDVLI
   181  RASACLEEAA RERDGLEQAL RRRESEHERE VRALYEETEQ LREQSRRPPS QNFARGERRS
   241  RLELELQSRE QDLERAGLRQ RELEQQLHAQ AAEHLEAQAQ NSQLWRAHEA LRTQLEGAQE
   301  QIRRLESEAR GRQEQTQRDV VAVSRNMQKE KVSLLRQLEL LRELNTRLRD DRDACEARRA
   361  GSSCRKALTT ARLPGPTCCC CCCWARPPRR GSGHLPSAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRACR2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 210 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 210 nTPM
pancreas: 136 nTPM
stomach: 53 nTPM
breast: 44 nTPM
prostate: 30 nTPM
colon: 29 nTPM

Single-cell type

breast lactating cells: 241 nCPM
breast hormone-responsive cells: 207 nCPM
breast secretory cells: 184 nCPM
salivary acinar cells: 158 nCPM
goblet cells: 148 nCPM
prostatic club cells: 146 nCPM

Immune cell

memory B-cell: 3.9 nTPM
eosinophil: 3.7 nTPM
basophil: 3.4 nTPM
naive B-cell: 3 nTPM
NK-cell: 1.7 nTPM
classical monocyte: 0.5 nTPM

Brain region

choroid plexus: 8 nTPM
cerebellum: 7.3 nTPM
hypothalamus: 4.6 nTPM
cerebral cortex: 4.5 nTPM
thalamus: 4.5 nTPM
pons: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

store-operated calcium entry

Molecular functions

calcium ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRACR2B as an antibody target. Whether an autoantibody or antibody against CRACR2B could matter depends on whether native CRACR2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRACR2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRACR2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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