Seroatlas · Human Serome Atlas

CRACDL

CRACD-like protein

Also known as: C2orf55, CRCDL_HUMAN, KIAA1211L, MGC42367

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NV74
Gene: CRACDL
Ensembl: ENSG00000196872
Chromosome: 2
Canonical length: 962 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Centrosome

OverviewNCBI Gene

No narrative summary is available for CRACDL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

962 residues, UniProt reviewed canonical sequence.

>Q6NV74|CRACDL
     1  MISTRVMDIK LREAAEGLGE DSTGKKKSKF KTFKKFFGKK KRKESPSSTG SSTWKQSQTR
    61  NEVIAIESGP VGYDSEDELE ESRGTLGSRA LSHDSIFIPE SGQDATRPVR VFSQENVCDR
   121  IKALQLKIQC NVKMGPPPPP GGLPAKRGED AGMSSEDDGL PRSPPEMSLL HDVGPGTTIK
   181  VSVVSPDHVS DSTVSARISD NSLAPVADFS YPAESSSCLD NSAAKHKLQV KPRNQRSSKM
   241  RRLSSRAQSE SLSDLTCTPE EEENEEKPLL EVSPEERPSS GQQDVAPDRG PEPGPPAPLP
   301  PPGGARARRA RLQHSSALTA SVEEGGVPGE DPSSRPATPE LAEPESAPTL RVEPPSPPEG
   361  PPNPGPDGGK QDGEAPPAGP CAPATDKAEE VVCAPEDVAS PFPTAIPEGD TTPPETDPAA
   421  TSEAPSARDG PERSVPKEAE PTPPVLPDEE KGPPGPAPEP EREAETEPER GAGTEPERIG
   481  TEPSTAPAPS PPAPKSCLKH RPAAASEGPA ASPPLAAAES PPVEPGPGSL DAEAAAPERP
   541  KAERAEAPPA GAERAAPERK AERGGAELRG AKKFSVSSCR ARPRPGVSRP LERASGRLPL
   601  ARSGPVWRSE AALDDLQGLP EPQHAKPGPR KLAERGPQDS GDRAASPAGP RKSPQEAAAA
   661  PGTREPCPAA QEPAPSEDRN PFPVKLRSTS LSLKYRDGAS QEVKGVKRYS AEVRLERSLT
   721  VLPKEEKCPL GTAPALRGTR APSDQGKGKA RPPEPLSSKP PLPRKPLLQS FTLPHQPAPP
   781  DAGPGEREPR KEPRTAEKRP LRRGAEKSLP PAATGPGADG QPAPPWITVT RQKRRGTLDQ
   841  PPNQEDKPGA RTLKSEPGKQ AKVPERGQEP VKQADFVRSK SFLITPVKPA VDRKQGAKLN
   901  FKEGLQRGIS LSHQNLAQSA VMMEKELHQL KRASYASTDQ PSWMELARKK SQAWSDMPQI
   961  IK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRACDL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 35 nTPM
epididymis: 30 nTPM
basal ganglia: 28 nTPM
fallopian tube: 21 nTPM
hippocampal formation: 19 nTPM
amygdala: 18 nTPM

Single-cell type

epididymal principal cells: 449 nCPM
respiratory ciliated cells: 298 nCPM
corticotrophs: 248 nCPM
fallopian tube ciliated cells: 173 nCPM
brain excitatory neurons: 164 nCPM
brain inhibitory neurons: 131 nCPM

Immune cell

eosinophil: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 110 nTPM
hippocampal formation: 108 nTPM
basal ganglia: 91 nTPM
amygdala: 72 nTPM
white matter: 56 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRACDL as an antibody target. Whether an autoantibody or antibody against CRACDL could matter depends on whether native CRACDL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRACDL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRACDL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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