Seroatlas · Human Serome Atlas

CPXCR1

CPX chromosomal region candidate gene 1 protein

Also known as: CPXCR_HUMAN, CT77

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N123
Gene: CPXCR1
Ensembl: ENSG00000147183
Chromosome: X
Canonical length: 301 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is one of several genes identified in a region of the X chromosome associated with an X-linked cleft palate (CPX) disorder. The encoded protein contains a motif similar to a motif found in zinc-finger proteins. Mutation analysis of this gene has not revealed any mutation which causes the CPX disorder. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q8N123|CPXCR1
     1  MSYPTKEGSD TAGNAHKNSE NEPPNDCSTD IESPSADPNM IYQVETNPIN REPGTATSQE
    61  DVVPQAAENS ELETEIQKDQ REEDLKEELL LLQTPIPRKL VSHKPLNDRS RSHSGKVEMK
   121  ANNFPINHKT RFRLSTSWRV PFINSHEIRS MILHLLCDRY FSQAAGCQNT MWVKRKYIAC
   181  LYHPNSFTHH ERAITFRRPS RVHYYRPLTE RMTSGKFCKS TDTKGKCRFR AIVRSVLFVS
   241  QIQIESIFNI KGFVDILTYI HTMNVMITNT NNGWKYFCPI CGRLFNTYSE LRQHSCSSSG
   301  N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPXCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

testis: 6 nTPM
fallopian tube: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 75 nCPM
early spermatids: 71 nCPM
late spermatids: 9.9 nCPM
respiratory ciliated cells: 0.9 nCPM
sertoli cells: 0.9 nCPM
undifferentiated spermatogonia: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.56
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPXCR1 as an antibody target. Whether an autoantibody or antibody against CPXCR1 could matter depends on whether native CPXCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPXCR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPXCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...