Seroatlas · Human Serome Atlas

CPTP

Ceramide-1-phosphate transfer protein

Also known as: CPTP_HUMAN, GLTPD1, MGC10334

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TA50
Gene: CPTP
Ensembl: ENSG00000224051
Chromosome: 1
Canonical length: 214 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol,Perinuclear theca,Flagellar centriole,Mid piece

OverviewNCBI Gene

Enables ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Involved in ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q5TA50|CPTP
     1  MDDSETGFNL KVVLVSFKQC LDEKEEVLLD PYIASWKGLV RFLNSLGTIF SFISKDVVSK
    61  LRIMERLRGG PQSEHYRSLQ AMVAHELSNR LVDLERRSHH PESGCRTVLR LHRALHWLQL
   121  FLEGLRTSPE DARTSALCAD SYNASLAAYH PWVVRRAVTV AFCTLPTREV FLEAMNVGPP
   181  EQAVQMLGEA LPFIQRVYNV SQKLYAEHSL LDLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPTP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 90 nTPM
liver: 70 nTPM
testis: 68 nTPM
skeletal muscle: 52 nTPM
esophagus: 49 nTPM
kidney: 35 nTPM

Single-cell type

late spermatids: 286 nCPM
esophageal apical cells: 273 nCPM
late primary spermatocytes: 137 nCPM
colonocytes: 82 nCPM
esophageal suprabasal cells: 67 nCPM
early spermatids: 66 nCPM

Immune cell

eosinophil: 6.1 nTPM
T-reg: 5.1 nTPM
memory B-cell: 3 nTPM
memory CD4 T-cell: 1.9 nTPM
basophil: 1.8 nTPM
gdT-cell: 1.6 nTPM

Brain region

pons: 33 nTPM
thalamus: 30 nTPM
hippocampal formation: 29 nTPM
medulla oblongata: 28 nTPM
choroid plexus: 27 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0.02
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ceramide transport
intermembrane lipid transfer
negative regulation of autophagy
negative regulation of interleukin-1 beta production
negative regulation of NLRP3 inflammasome complex assembly
ceramide 1-phosphate transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPTP as an antibody target. Whether an autoantibody or antibody against CPTP could matter depends on whether native CPTP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPTP is annotated at the cell surface, where native CPTP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPTP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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